Postdoctoral Fellowship

We are excited to invite applications for a postdoctoral fellow to join the Kozberg Lab at Massachusetts General Hospital (MGH) and Harvard Medical School.

The successful candidate will lead efforts to understand the mechanisms underlying blood vessel rupture in cerebral amyloid angiopathy (CAA) — a common small vessel disease and leading cause of intracerebral hemorrhage. CAA is characterized by amyloid-β deposition in the walls of cerebral vessels, and the mechanisms driving vessel rupture remain poorly understood. Your work will directly address this critical gap.

The Kozberg Lab is deeply motivated by the experiences of patients with CAA. Current projects focus on the contributions of blood-brain barrier leakage, prior brain bleeding, APOE genotype, and neuroinflammation to blood vessel dysfunction — studied at the individual vessel level using a combination of in vivo optical imaging and ex vivo histopathological approaches. Additionally, our lab aims to bridge findings in mouse models to human disease, with projects including immune cell profiling and in-vivo MR imaging of patients with CAA. Our overarching goal is to develop novel therapeutic strategies effective at the time patients first present with symptoms.

JOB DESCRIPTION

  • Lead experiments using in vivo two-photon microscopy and widefield optical imaging to longitudinally image cerebrovascular dynamics and vessel rupture events at single-vessel resolution in mouse models of CAA

  • Use ex vivo quantitative histopathology in mouse and human tissue to complement in vivo findings

  • Develop and apply image analysis pipelines

  • Integrate imaging data with molecular and histological readouts to build mechanistic models of CAA-related vascular dysfunction

CANDIDATE QUALIFICATIONS

  • A PhD and/or MD in neuroscience, biomedical engineering, physiology, or a closely related discipline

  • Genuine interest in cerebrovascular biology and translational neurology

  • Hands-on experience with in vivo two-photon microscopy

  • Proficiency in mouse surgery and in vivo rodent models of neurological disease

  • Comfort with quantitative image analysis; experience with MATLAB, Python, ImageJ/FIJI, or similar tools is highly valued

  • Collaborative spirit, intellectual curiosity, and a drive to develop as an independent scientist

  • Strong written and oral communication skills and a track record of first-author publications

WHY JOIN US

The Kozberg Lab is a growing, collaborative, and inclusive research group embedded in the rich scientific ecosystem of Massachusetts General Hospital and Harvard Medical School. You will have access to state-of-the-art imaging infrastructure and a vibrant network of cerebrovascular, clinical, and basic science collaborators. Fellows receive dedicated mentorship and are empowered to pursue independent scientific questions with the goal of launching successful independent careers.

To apply, send a cover letter describing your research interests and CV to mkozberg@mgh.harvard.edu.